15th International Conference on Frontotemporal Dementias – Oct. 8-11, 2026

We are thrilled to invite you to the 15th International Conference on Frontotemporal Dementias (ISFTD 2026) in the vibrant city of Philadelphia, Pennsylvania! Join us from October 8-11, 2026 for the opportunity to enhance your expertise, explore cutting-edge research, and connect with leading experts in the field from around the world.

Thursday, October 8, 2026
8:00 AM - 12:00 PM
Salon I
Pre-Conference Workshop: State-of-the-Art Technologies to Advance the Next Generation of FTD Researchers - Track A: “An Introduction to FTD” (Separate Registration Required)
8:00 AM - 8:25 AM
Behavioral Variant Frontotemporal Dementia
Speaker: Olivier Piguet (University of Sydney)
Moderator: Corey McMillan (USA)
8:25 AM - 8:50 AM
Primary Progressive Aphasia
Speaker: Marsel Mesulam (USA)
Moderator: Corey McMillan (USA)
8:50 AM - 9:15 AM
Progressive Supranuclear Palsy and Corticobasal Syndrome
Speaker: James Rowe (UK)
Moderator: Corey McMillan (USA)
9:15 AM - 9:40 AM
ALS-FTD
Speaker: Michael Strong (Canada)
Moderator: Corey McMillan (USA)
9:40 AM - 10:00 AM
Clinical Outcome Measures for FTD Trials
Speaker: Howie Rosen (USA)
Moderator: Corey McMillan (USA)
10:00 AM - 10:15 AM
Coffee Break
10:15 AM - 10:40 AM
Genetics of FTD
Speaker: Vivianna Van Deerlin (USA)
Moderator: David Irwin (USA)
10:40 AM - 11:05 AM
FTLD-TDP and FTLD-FET
Speaker: Manuela Neumann (Germany)
Moderator: David Irwin (USA)
11:05 AM - 11:30 AM
FTLD-Tau
Speaker: Dennis Dickson (USA)
Moderator: David Irwin (USA)
11:30 AM - 12:00 PM
Interactive Digital Pathology Session: Review of Digital Images of Exemplar FTLD Pathology with Audience Participation
Moderator: David Irwin (USA)
8:00 AM - 12:00 PM
Salon K
Pre-Conference Workshop: State-of-the-Art Technologies to Advance the Next Generation of FTD Researchers - Track B: “Advanced Techniques in FTD Research” (Separate Registration Required)
8:00 AM - 8:25 AM
Spatial-Omics From Postmortem Tissue in ALS-FTD
Speaker: Hemali Phatnani (USA)
Moderator: David Irwin (USA)
8:25 AM - 8:50 AM
Cryo-EM Approaches to Study Protein Aggregates
Speaker: Edward Lee (University of Pennsylvania)
Moderator: David Irwin (USA)
8:50 AM - 9:15 AM
Open-Source Digital Pathology
Speaker: Paul Yushkevich (USA)
Moderator: David Irwin (USA)
9:15 AM - 10:00 AM
Hands-on Digital Pathology Session: Interactive Digital Pathology Demonstration of Image Thresholding, Segmentation and Object Detection
Speaker: Daniel Ohm (University of Pennsylvania)
Moderator: David Irwin (USA)
10:00 AM - 10:15 AM
Coffee Break
10:15 AM - 10:40 AM
Strategies for Identifying Prodromal Behavior & Cognition in Genetic FTD & ALS
Speaker: Ted Huey (USA)
Moderator: Corey McMillan (USA)
10:40 AM - 11:05 AM
Computational Analysis of Digital Speech Samples in PPA
Speaker: Bradford Dickerson (USA)
Moderator: Corey McMillan (USA)
11:05 AM - 11:30 AM
Digital Metrics of Connected Speech
Speaker: Jet Vonk (USA)
Moderator: Corey McMillan (USA)
11:30 AM - 12:00 PM
Informatic Approaches to Big Data
Speaker: Adam Staffaroni (USA)
Moderator: Corey McMillan (USA)
12:00 PM - 1:00 PM
Salon I
EMCR/Senior Researcher Luncheon Mixer
1:00 PM - 1:15 PM
Salon H
Opening Ceremony
Speaker: Olivier Piguet (University of Sydney)
1:15 PM - 1:30 PM
Salon H
A Historic Neuropathological Perspective of FTD
Speaker: Virginia Lee
1:30 PM - 1:45 PM
Salon H
Presidential Lecture
Speaker: Olivier Piguet (University of Sydney)
1:45 PM - 3:15 PM
Salon H
Plenary Session 1 - Update on Clinical Syndromes
1:45 PM - 2:15 PM
Right Temporal Variant FTD
Speaker: Hulya Ulugut (USA)
2:15 PM - 2:45 PM
Lateralized Atrophy and Emotions in FTD
Speaker: Virginia Sturm (USA)
2:45 PM - 3:15 PM
Redefining the ALS-FTD Spectrum: Biological & Clinical Considerations
Speaker: Michael Strong (Canada)
3:15 PM - 3:45 PM
Franklin Hall B
Coffee Break / Visit Exhibits
3:45 PM - 5:15 PM
Salon H
Abstracts Session 1.1 - Behaviour / Cognition / Language
3:45 PM - 4:00 PM
Automated Speech Analysis Identifies Clinical, Anatomical, and Pathological Variants of Primary Progressive Aphasia (#1001)
Speaker: Jet M.J. Vonk (University of California, San Francisco)
4:00 PM - 4:15 PM
Predicting Amyloid Status in Primary Progressive Aphasia Using Explainable Artificial Intelligence (#1002)
Speaker: Neguine Rezaii (Harvard Medical School)
4:15 PM - 4:30 PM
Clinically Validated Population Based Real World Data Reveal the Long Prodromal Phase and Societal Impact of Frontotemporal Dementia (#1003)
Speaker: Eino Solje (University of Eastern Finland)
4:30 PM - 4:45 PM
The Causes of Prevalence Differences by Sex in Sporadic Behavioural Variant Frontotemporal Dementia (#1004)
Speaker: Nol Swaddiwudhipong (University of Cambridge)
4:45 PM - 5:00 PM
Social Cognition Measures Support Differential Diagnosis of BvFTD, Psychiatric Disorders, and Alzheimer’s Disease (#1005)
Speaker: Jan Van den Stock (KU Leuven)
5:00 PM - 5:03 PM
First Mexican Cohort of Frontotemporal Dementia at a Tertiary Cognitive Neurology Clinic (#1006)
Speaker: Ramiro Ruíz-García (Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez")
5:03 PM - 5:06 PM
Performance on Gene Specific Cognitive Composites (GENFI-Cog) in the Genetic Frontotemporal dementia (GENFI) Study (#1007)
Speaker: Victoria Pauwels Romero (University College London)
5:06 PM - 5:09 PM
The Dutch Mini-Linguistic State Examination (MLSE-NL): Findings in Primary Progressive Aphasia (PPA) (#1008)
Speaker: Lize Jiskoot (Erasmus Medical Centre)
5:09 PM - 5:12 PM
Left-Predominant Semantic Variant PPA and Right Temporal Variant FTD Exhibit Distinct Verbal-Semantic and Behavioral Phenotypes in an East Asian Cohort (#1009)
Speaker: Suah Kim (Samsung Medical Center)
5:12 PM - 5:15 PM
Cross-Linguistic Speech Timing Measures in Primary Progressive Aphasia: An Australian and Spanish Study (#1010)
Speaker: Lucia Fernandez-Romero (The University of Texas at Austin)
3:45 PM - 5:15 PM
Salon I-L
Abstracts Session 1.2 - Neuropathology
3:45 PM - 4:00 PM
Agentic Generative Artificial Intelligence Architecture for Classification of Pathology-Confirmed Primary Progressive Aphasia Variants (#1011)
Speaker: Chiara Gallingani (University of Modena and Reggio Emilia)
4:00 PM - 4:15 PM
ANXA11 as Additional Pathological Marker for Tdp-43 Classification: A Post-Mortem Case Series of Rare Genetic, Mixed and Unclassifiable TDP-43 Pathologies (#1012)
Speaker: Ana Rajicic (Erasmus University Medical Center)
4:15 PM - 4:30 PM
Discovery of a Novel and Specific Co-Aggregate Of pTDP-43 in svPPA (#1013)
Speaker: Sevinc Jakab (Department of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA)
4:30 PM - 4:45 PM
Superficial PPARG-Expressing Excitatory Neurons Are Selectively Vulnerable in the Medial Orbitofrontal Cortex of Behavioral Variant Frontotemporal Dementia (#1014)
Speaker: Edward Lee (University of Pennsylvania)
4:45 PM - 5:00 PM
Spatial Transcriptomics Reveals Mechanisms of Hemispheric Asymmetry in TDP-C Frontotemporal Degeneration (#1015)
Speaker: Brian Druciak (Northwestern University)
5:00 PM - 5:03 PM
Modeling the Selective Predilection of TDP-C Through Normal Annexin A11 Distribution (#1016)
Speaker: Allegra Kawles (Northwestern University Feinberg School of Medicine)
5:03 PM - 5:06 PM
Identification of Novel TDP-43 Phosphorylation Sites With Potential Impact in Disease Pathogenesis (#1017)
Speaker: Antonia Mayer (DZNE Tübingen)
5:06 PM - 5:09 PM
Pathologic Correlates of White Matter Hyperintensities on Post-Mortem MRI in Frontotemporal Lobar Degeneration (FTLD) (#1018)
Speaker: Kimiko Domoto-Reilly (University of Washington)
5:09 PM - 5:12 PM
FTLD-TDP Type C: Regional Progression and Relationship To ANXA11 (#1019)
Speaker: Kristen Fernhoff (University of California San Francisco)
5:12 PM - 5:15 PM
Machine Learning Reveals Cortical Tau Pathology Patterns Across Clinicopathologic Subtypes of Progressive Supranuclear Palsy (#1020)
Speaker: Klara Gawor (University of Pennsylvania)
5:15 PM - 7:00 PM
Franklin Hall B
Poster Session 1 / Welcome Reception / EMCR Reception
Differentiating Semantic Variants of PPA and FTD using Automated Speech Analysis (#1021)
Speaker: Nikki Sisodia (University of California, San Francisco)
Association Between Postmortem Pathologic Burden and the Rate of Clinical Progression in Patients with Frontotemporal Lobar Degeneration (#1022)
Speaker: Rogan Magee (University of Pennsylvania)
Determination of Decision-Making Capacity According to Dementia Subtype (#1023)
Speaker: Melissa Bendayan (University of Chicago)
TMEM106B C-terminus Immunoreactivity Is Associated With Cortical Atrophy in a Post-Mortem In-Situ MRI FTD Cohort (#1024)
Speaker: Alex Wesseling (Amsterdam UMC)
Molecular Dissection of Cell Type-Specific Tau Conformers and Heterogeneity in Pick’s Disease (#1025)
Speaker: Soljee Yoon (University of California, San Francisco)
Plasma Complexin Synaptic Composite as a Blood Marker of Tau-Related Synaptic Dysfunction in Frontotemporal Dementias (#1026)
Speaker: Edward N. Wilson (Brown University)
Limited Transferability of AI Foundation Models for Automated FTLD Tau and TDP-43 Inclusion Type Classification (#1027)
Speaker: Hyung Seok Roh (University of Pennsylvania)
Barcelona Scale for Buccophonatory Apraxia: Task‑Level Motor Profiles in Primary Progressive Aphasia (#1028)
Speaker: Núria Montagut (Hospital Clínic de Barcelona)
Primary Progressive Aphasia in Patients with Positive or Negative Alzheimer’s Disease Biomarkers: A Preliminary Case Review (#1029)
Speaker: Victoria Sanborn (Brown University)
Cerebral Blood Flow Signatures of Primary Progressive Aphasia: An Arterial-Spin-Labelling (ASL) MRI Study (#1030)
Speaker: Yuan Tao (Johns Hopkins University)
Cognitive Disease Progression Subtypes in Genetic Frontotemporal Dementia: A Data-Driven Approach Using the GENFI Cohort (#1031)
Speaker: Lucy Chisman-Russell (University College London)
Sustained Slowing of Cognitive-Linguistic Decline Following Long-Term Booster Neuromodulation in Logopenic Primary Progressive Aphasia: A 3-Year Case Study (#1032)
Speaker: Donna Tippett (Johns Hopkins University School of Medicine)
Beyond Apathy: Impaired Inhibitory Control as a Neurocognitive Explanation for the Apathy-Disinhibition Paradox (#1033)
Speaker: Jordan Sibley (FRONTIER Frontotemporal Dementia Research Clinic)
A Novel Digital Task for Remote Assessment of Visuoconstruction and Memory (#1034)
Speaker: Ashley Heywood (University of California, San Francisco)
Automated Analysis of Expressive Prosody in Dutch Patients With Behavioural Variant Frontotemporal Dementia and Primary Progressive Aphasia (#1035)
Speaker: Lize Jiskoot (Erasmus Medical Centre)
In Vivo TSPO PET In Pathologically Heterogeneous Frontotemporal Dementia Reflects Increased Phagocytic Microglial Markers at Post Mortem (#1036)
Speaker: Davi Schramm Vontobel (University of Cambridge)
Sex Differences for Clinical Presentations and Co-Pathologies in Progressive Supranuclear Palsy and Corticobasal Degeneration (#1037)
Speaker: Isabela Romano (University of Colorado Anschutz)
Elevation of Cerebrospinal Fluid of Interferon-Stimulated Gene 15 (ISG15) is a Distinct Feature of FTLD-TDP Type C (#1038)
Speaker: Peter A. Ljubenkov (University of California, San Francisco, Weill Institute for Neurosciences, Edward and Pearl Fein Memory and Aging Center)
Myo-Inositol: A Spectroscopic Marker of Neuroinflammation in Frontotemporal Lobar Degeneration (#1039)
Speaker: Sean Tan (University of Cambridge)
Micro- and Macro-Scale Covariance Networks in Frontotemporal Lobar Degeneration Proteinopathies (#1040)
Speaker: Min Chen (University of Pennslyvania)
The Clinical Relevance of Practice Effects Resulting from Frequent Smartphone Assessments in Frontotemporal Lobar Degeneration (#1041)
Speaker: Mark Sanderson-Cimino (University of California San Francisco)
Impact of Awareness of Genetic Status on Cognitive, Behavioral, and Neuropsychiatric Outcomes in Genetic Frontotemporal Dementia (#1042)
Speaker: Liset de Boer (Erasmus MC)
Functional Connectivity Is Associated With Tau Burden and Accumulation in Primary Progressive Aphasia (#1043)
Speaker: Adam Martersteck (University of Chicago)
Greater Excitatory-Inhibitory Imbalance in Tauopathies Than TDP-43 Proteinopathies of Behavioral Variant Frontotemporal Dementia (#1044)
Speaker: Daniel Ohm (University of Pennsylvania)
Anomia across the Frontotemporal Dementia Spectrum (#1045)
Speaker: Shalom Henderson (Bonston University)
Increased Fail Rates on Performance Validity Testing in Patients With Behavioral Variant Frontotemporal Dementia. (#1046)
Speaker: Talia Kunin (Vanderbilt University Medical Center)
The Contribution of the Temporo-Frontal Extreme Capsule Fasciculus and Uncinate Fasciculus to Semantic Processing in Primary Progressive Aphasia (#1047)
Speaker: Kyriaki Neophytou (University of Nicosia, UNIC Athens)
The Impact of the White Matter Hyperintensities to the Cognitive Function in the Patients With Behavioral Variant Frontotemporal Dementia (#1048)
Speaker: Bon D. Ku (International St. Mary’s Hospital, Catholic Kwandong University College of Medicine)
FTLD-TDP Type C Proteomics: Comparison to Alzheimer Disease and to Other TDP-43 Proteinopathies (#1049)
Speaker: Rik Vandenberghe (University Hospitals Leuven)
Presence of Misfolded Tau Conformations Within the Retinas of FTLD-Tau Patients (#1050)
Speaker: Benjamin Kim (University of Pennsylvania)
Distinct Speech Profiles and Atrophy Trajectories Differentiate 4R-Tauopathies in Primary Progressive Aphasia (PPS) (#1051)
Speaker: Viktoria Zilkova (Northwestern University)
Movement Disorder and Cognition in Frontotemporal Dementia and Atypical Parkinsonism (#1052)
Speaker: Olivier Piguet (University of Sydney)
Dissociable Neural Correlates of Anosognosia and Anosodiaphoria in Behavioral Variant Frontotemporal Dementia: A Voxel-Based Morphometry Study (#1053)
Speaker: FEDERICA PALACINO (Neurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.)
Cognitive and Gray Matter Profiles in Youths With Frontotemporal Lobar Degeneration Genetic Variants (#1054)
Speaker: Youjin Jung (University of California, San Francisco)
Morphological analysis of microglia using automated segmentation of IBA1 in FTLD-TDP (#1055)
Speaker: Noah Capp (University of Pennsylvania)
Normative Data for the MoCA - Language (MoCA-L): Normative Data for the Moca - Language (Moca-L): Expanding Cognitive Screening to Language Deficits in Neurocognitive Disorders (#1056)
Speaker: Robert Laforce (CHU de Québec-Université Laval)
Semantic and Phonemic Fluency: Demographic and Cardiovascular Risk Associations in the LatAm-FINGERS Costa Rica Cohort (#1057)
Speaker: Sylvia Josephy-Hernandez (San Juan de Dios Hospital, Caja Costarricense de Seguro Social)
Quantitative Susceptibility Mapping With MRI Reveals Focal Iron Accumulation Associated With Symptomatic c9orf72-Associated Behavioral-Variant Frontotemporal Dementia (#1058)
Speaker: Shraddha R. Pandey (Perelman School of Medicine, University of Pennsylvania)
Subregional Orbitofrontal Cortex Quantification of Pathology Burden in TDP-C (#1059)
Speaker: Helen Cai (University of Pennsylvania)
Digital Phenotyping of Apathy and Anhedonia Inventral Anterior Insula as a Disrupted Gating Hub: Altered Directional Communication Among Salience, Default Mode, and Frontoparietal Networks Impairs Social Inference in BvFTD (#1060)
Speaker: Yu Chen (University of California, San Francisco)
C9orf72-Associated Parkinsonism: Defining a Multisystem Neurodegenerative Spectrum (#1061)
Speaker: Jamir Pitton Rissardo (Cooper University Hospital)
Atrophy-Related Inflammation CSF Markers Predict Clinical Progression in Genetic Frontotemporal Dementia (#1062)
Speaker: Noah Shapiro (University of Cambridge)
Thalamic Volume Loss Specific to c9orf72-Related Pathology Revealed by Ultra-High Resolution Ex Vivo 7T MRI (#1063)
Speaker: Noah Schweitzer (University of Pennsylvania)
Divergent Mechanisms of Anomia in Alzheimer’s Disease Versus FTLD-TDP-C with Primary Progressive Aphasia (#1064)
Speaker: Elena Barbieri (Northwestern Unviersity)
Utility of a Machine Learning–Based Addenbrooke’s Cognitive Examination-III Subtyping Tool for Primary Progressive Aphasia and Alzheimer’s Disease (#1065)
Speaker: Olivier Piguet (University of Sydney)
Differential Microglial Involvement in White and Grey Matter in Frontotemporal Dementia (#1066)
Speaker: Harry Crook (University of Cambridge)
Assessment of Insight Into Symptoms in Addition to Behavioural Features Improves Discrimination Between Behavioural Variant Frontotemporal Dementia and Major Depressive Disorder (#1067)
Speaker: Steven Wezel (University Hospital Basel)
The Interplay Between Emotional and Cognitive Reserve in Frontotemporal Dementia: Evidence From Functional Connectivity and Structural Atrophy (#1068)
Speaker: Anna Gilioli (IRCCS San Raffaele Scientific Institute, Milan)
Automated Metrics Reveal Differential Connected Speech Disruptions In nfvPPA and bvFTD (#1069)
Speaker: Agustina Birba (Cognitive Neuroscience Center (CNC), Department of Life and Behavioral Sciences, University of San Andres, Buenos Aires, Argentina)
Automated Speech Analysis of Smartphone Recordings Marks Early Impairment in Prodromal Familial Frontotemporal Dementia (#1070)
Speaker: Jet M.J. Vonk (University of California, San Francisco)
Emotional Brain Responses and Pattern Expressions in Right Temporal Variant Frontotemporal Dementia (#1071)
Speaker: Jonathan Adams (KU Leuven)
A Portable Eye Tracking Experiment for the Assessment of Social Cognition Across the FTD-ALS Spectrum (#1072)
Speaker: Rhian Convery (University College London)
An Eye-Tracking Adaptation of the Trail Making Test Reveals Patterns of Gaze Behavior in Genetic Frontotemporal Dementia (#1073)
Speaker: Liset de Boer (Erasmus MC)
Individual-Level Neurophysiological Markers of the Language Network in Healthy Aging and Asymptomatic FTD Mutation Carriers (#1074)
Speaker: Rose Bruffaerts (University of Antwerp)
Lifestyle Activity and Clinical Severity in Familial Frontotemporal Dementia (#1075)
Speaker: Eva Cullen (University College London)
Expanding the Clinical Spectrum of TDP-43/ANXA11 Co-Pathology in FTLD-TDP (#1076)
Speaker: Merel Zuijdweg (University of Amsterdam, Swammerdam Institute for Life Science)
Graph Theory Analysis of Network Alteration in Primary Progressive Aphasia Due to Underlying AD and TDP-43 Type C (#1077)
Speaker: Elena Barbieri (Northwestern Unviersity)
Auditory Agnosia in Primary Progressive Aphasia: Clinical, Neuroimaging, and Neuropathological Features (#1078)
Speaker: Hiroyuki Watanabe (Mayo Clinic, Rochester, MN, USA)
Effects of Sex, Age and Education on Clinical Progression in Behavioral Variant Frontotemporal Dementia (#1079)
Speaker: Nastasia Mitrikeski (Douglas Research Center)
Right Temporal Variant Frontotemporal Dementia Due to FTLD-FET Confirmed By Neuropathology (#1080)
Speaker: SERGI BORREGO (Hospital Clinic Barcelona)
Divergent Multimodal Longitudinal GM–WM Relationships Reflect Distinct Disease Mechanisms in svPPA and naPPA (#1081)
Speaker: Runtian Miao (University of Pennsylvania)
Primary Progressive Aphasia as a Continuous Phenotypic Space: A Data-Driven Convex Hull Approach (#1082)
Speaker: Sarah Maso (Toulouse NeuroImaging Center (Tonic-Inserm))
Acoustic Speech Metrics Derived From Repetition for Differential Diagnosis of Primary Progressive Aphasia Variants in Spanish: Effects of Task Type and Word Structure (#1083)
Speaker: Miguel Santos-Santos (Sant Pau Memory Unit, IR Sant Pau, Hospital de la Santa Creu i Sant Pau)
Natural Language Processing of Conversational Speech in Primary Progressive Aphasia Variants (#1084)
Speaker: Spencer Price (Yale University)
EEG Signature of Logopenic Variant Primary Progressive Aphasia: Evidence from Resting-State Brain Rhythms (#1085)
Speaker: Panteleimon Chriskos (Johns Hopkins University, School of Medicine)
Toward a Linguistically Tailored Diagnostic Framework for Chinese Primary Progressive Aphasia (#1086)
Speaker: Boon Lead Tee (University of California, San Francisco)
Analysis of the Mayo Sleep Questionnaire in Genetic FTLD at an ALLFTD Site (#1087)
Speaker: Makayla Kelleher (Mayo Clinic)
Cerebellar Subregions Support Social Cognition in Early Behavioral Variant Frontotemporal Dementia (#1088)
Speaker: Yu Chen (University of California, San Francisco)
Social Cognitive Dysfunction Across the Alzheimer’s Disease Spectrum: Facial Emotion Recognition and Its Neural Correlates (#1089)
Speaker: YongSoo Shim (The Catholic University of Korea, St. Vincent's Hospital)
Cognitive and Behavioral Trajectories in the Pre-dementia TDP-43 Spectrum (#1090)
Speaker: Judit Selma-González (Sant Pau Memory Unit, IR Sant Pau, Hospital de la Santa Creu i Sant Pau)
Theory of Mind Deficits in Patients With Behavioral Variant Frontotemporal Dementia - Using the Basel Version of the Awareness of Social Inference Test - Theory of Mind (#1091)
Speaker: Steven Wezel (University Hospital Basel)
A Deep-Learning Model of Structural Brain Aging Is Sensitive to Cognitive Impairment and Underlying Pathology in Behavioral and Dysexecutive Dementia Syndromes (#1092)
Speaker: Jeff Phillips (University of Pennsylvania)
Social Cognition Screening Tool in a Memory Clinic: Lessons from the Field (#1093)
Speaker: Brendan Braatz (Geisinger Commonwealth School of Medicine)
Bilingualism as Cognitive Reserve Across ADRD Syndromes: A Longitudinal Analysis (#1094)
Speaker: Shwetha Kandhalu Bhaskar (University of California, San Francisco)
Differential Patterns of Tau Burden and Neuroinflammation in bvFTD and PPA due to Pick’s Disease (#1095)
Speaker: Rachel Keszycki (Northwestern University)
Effects of first line PMOS Therapies on Executive Functioning (#1096)
Speaker: Emma Bernstein (Hospital of the University of Pennsylvania)
Laminar Diffusion MRI Alterations Mirror Intracortical Neuropathological Distribution in Frontotemporal Lobar Degeneration (#1097)
Speaker: Mario Torso (Oxford Brain Diagnostics)
The Added Diagnostic Value of Social Cognition in Distinguishing Behavioural Variant Frontotemporal Dementia from Primary Psychiatric Disorders (#1098)
Speaker: Simon Ducharme (Douglas Institute)
Cortical Neurofibrillary Tangles Are More Severe and More Variable in Atypical and Early-Onset Alzheimer’s Disease (#1099)
Speaker: John Robinson (University of Pennsylvania)
Disease Progression and Associated Atrophy in Primary Progressive Apraxia of Speech (#1100)
Speaker: Syedah Khadeeja Shah (Brigham and Womewn's Hospital)
Navigating the landscape of ANXA11 proteinopathies (#1101)
Speaker: Nikhil Ghayal (Mayo Clinic Florida)
The Famous Faces Maugeri Evaluation (FAME): Development of a New Ecologic Tool for Famous‑Face Recognition Aimed at Detecting the Right‑Temporal Variant FTD (#1102)
Speaker: Maxime Montembeault (Douglas Research Centre & Department of Psychiatry, McGill University, Montreal, Canada)
The Influence of Clinical Features and Alzheimer’s Disease Biomarkers on the Diagnostic Trajectory of Suspected 4R-Tauopathies (#1103)
Speaker: Salomón Salazar-Londoño (Amsterdam UMC)
Detecting Presymptomatic Speech and Language Changes in Genetic Frontotemporal Dementia With Natural Language Processing (#1104)
Speaker: Arabella Bouzigues (Douglas Research Centre, McGill University)
Linguistic Taxonomy of Phonemic Verbal Fluency in Frontotemporal Dementia (#1105)
Speaker: Alejandra Pelaez (Pontificia Universidad Javeriana)
Distinct Patterns of Social Semantic Processing in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Evidence From the Dynamic Actions Semantic Congruency Task (#1106)
Speaker: Deissy Milena Garcia García (Hospital Universitario Fundación Santa Fe, Hospital Universitario San Ignacio)
Voice Measures and Motor Impairment in Frontotemporal Degeneration (#1107)
Speaker: Kiiya Shibata (Vanderbilt University)
Auditory-Perceptual Rating of Connected Speech in PPA/FTD: Preliminary Reliability Evidence (#1108)
Speaker: Kiiya Shibata (Vanderbilt University)
Structural Heterogeneity in PSP Tau (#1109)
Speaker: Sacha Salphati (University of Pennsylvania)
Characterization of Exosomes Isolated from FTLD Cortex with TDP-43 Proteinopathy and TDP-43 Transgenic Mice (#1110)
Speaker: Ivan Ayala (Northwestern University)
A Network Model of Sensory Hypersensitivity and Tinnitus in Semantic Dementia (#1111)
Speaker: Peter Pressman (Oregon Health & Science University)
The inaugural International Conference on Primary Progressive Aphasia (ICPPA): A Report of Proceedings (#1113)
Speaker: Maya Henry (University of Texas at Austin)
Unclassifiable Primary Progressive Aphasia: Evidence From a Pathology-Confirmed Cohort (#1114)
Speaker: Florentina Morello-Garcia (Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA)
Feature-Driven Characterization of Motor Speech Disorders in Nonfluent Variant Primary Progressive Aphasia (#1115)
Speaker: Lynn Kurteff (University of California, San Francisco)
Generation of Pick’s Disease Mouse Model by Introducing a tau Mutation Derived From a Pick’s Disease Patient (#1117)
Speaker: MASATO HOSOKAWA (Fukuoka University)
Large-Scale Proteomics Links TDP-43 Pathology to Adaptive Immune Responses in FTLD braiS (#1118)
Speaker: Vidhya Bharathi Maheswari Jawahar (University of Miami)
Friday, October 9, 2026
8:30 AM - 10:00 AM
Salon H
Plenary Session 2 - Biomarker / Epidemiology
8:30 AM - 9:00 AM
Mapping the Exposome and Biomarker Signatures of Frontotemporal Dementia Across Latin America
Speaker: Agustin Ibañez (Chile)
9:00 AM - 9:30 AM
RNA Dysregulation and Cryptic Splicing in TDP-43 Proteinopathy as Biomarker
Speaker: Pietro Fratta (UK)
9:30 AM - 9:45 AM
Phenoconversion Prediction in Genetic FTD Using Machine Learning Models on Structural and Diffusion MRI Data (#2001)
Speaker: Tine Swartenbroekx (Erasmus Medical Center Rotterdam)
9:45 AM - 10:00 AM
Interpretable MRI-Based Deep Learning for Classification of Alzheimer’s Disease and Behavioural Variant Frontotemporal Dementia in a Real-World Multicenter Cohort (#2002)
Speaker: Francesca Orlandi (Ospedale San Raffaele)
10:00 AM - 10:30 AM
Franklin Hall B
Coffee Break / Visit Exhibits
10:30 AM - 12:00 PM
Salon H
Abstracts Session 2 - Biomarker / Imaging
10:30 AM - 10:45 AM
Multi-Platform Cerebrospinal Fluid Proteomics Identifies and Validates MMP10 as a Diagnostic Biomarker for Pick’s Disease (#2003)
Speaker: Rowan Saloner (University of California, San Francisco)
10:45 AM - 11:00 AM
Multiplex Blood-Based Proteomic Profiling Distinguishes Clinical Syndromes and Reveals Immune Pathways Associated With Neurodegeneration and Survival in Frontotemporal Lobar Degeneration (#2004)
Speaker: Meira van Schaik (University of Cambridge)
11:00 AM - 11:15 AM
Large-Scale Proteomics Identifies Blood-Based Markers of Presymptomatic Disease in Familial Frontotemporal Lobar Degeneration (#2005)
Speaker: Connor Dietz (University of California, San Francisco)
11:15 AM - 11:30 AM
Digital Word Property Markers for Detecting Semantic Variant Primary Progressive Aphasia in Spanish-Speaking Latinos (#2006)
Speaker: Ivan Caro (Cognitive Neuroscience Center, Department of Life and Behavioral Sciences, Universidad de San Andrés, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Buenos Aire)
11:30 AM - 11:45 AM
FTLD-TDP and FTLD-tau Show Distinct Spatiotemporal Neuroimaging Signatures in Vivo (#2007)
Speaker: Sophie Matis (The University of Sydney)
11:45 AM - 11:48 AM
Structural Neuroimaging Signatures Discriminate Neuropathologies in Agrammatic Primary Progressive Aphasia (#2008)
Speaker: Elena Barbieri (Northwestern Unviersity)
11:48 AM - 11:51 AM
Tracking Early Neurophysiological Changes in Frontotemporal Dementia Using the Oura Ring (#2009)
Speaker: Amelia Blesius (University College London)
11:51 AM - 11:54 AM
Classifying Frontotemporal Dementia Subtypes Using MRI and Deep Transfer Learning (#2010)
Speaker: Samuel Warren (The University of Sydney)
11:54 AM - 11:57 AM
Alzheimer’s Disease Co-Pathology in Frontotemporal Dementia: Prevalence and Impact on Survival (#2011)
Speaker: Paula Vanneste (Alzheimer Center Amsterdam, Amsterdam UMC)
11:57 AM - 12:00 PM
Serum and CSF NULISA(tm) Biomarker Signatures and Clinical Associations in Behavioral-Variant Frontotemporal Dementia (#2012)
Speaker: Cem Doğdu (German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany)
12:00 PM - 1:30 PM
Franklin Hall B
Poster Session 2 / Lunch
Standardized Video-Based Genetics Education Improves Care Partner and Genetic Counseling Outcomes in Frontotemporal Degeneration (#2013)
Speaker: Laynie Dratch (University of Pennsylania)
Benefits and Efficacy of a Primary Progressive Aphasia Support Group (PPA-SG): A Pilot Project (#2014)
Speaker: Daphne Phillips (Mayo Clinic)
Phase 1B/2A Biomarker Readout: Inhibition of Progranulin Binding to Sortilin With VES001 Normalizes Progranulin Levels and Engages Lysosomal and Synaptic Pathways in GRN Mutation Carriers (#2015)
Speaker: Nina Schultz (Vesper Bio)
New Diagnosis Office Hours: An Introduction to Support and Resources after an FTD Diagnosis (#2016)
Speaker: Amy Almeida (Northwestern University)
High Interest in Onset-Predictive Biomarker Testing in Americans at Risk of Genetic FTD (#2017)
Speaker: Charlotte Graafland (Erasmus University Medical Center)
Clinical Utility of Plasma Neurofilament Light Chain in Frontotemporal Dementia Based on the Certainty of Diagnosis (#2018)
Speaker: Paula Canasto (Hospital Clínic de Barcelona)
Blood-Based Synaptic Biomarkers in Frontotemporal Dementia: Insights from the BioMarker Initiative for Mental and Neurodegenerative Disorders (BIOMIND) Cohort (#2019)
Speaker: Julia Peris-Subiza (Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain)
Inhomogeneous Magnetization Transfer (IhMT) Provides a Novel Neuroimaging Tool for Characterizing Myelin in FTD (#2020)
Speaker: Christopher Olm (University of Pennsylvania)
Understanding Cognitive Resilience in Behavioural-Variant Frontotemporal Degeneration Using a Mismatch Approach (#2021)
Speaker: Thakshila Dasanayake (Pennsylvania State University)
Cure MAPT FTD: Non-Profit Patient Advocacy Organization (#2022)
Speaker: Linde Jacobs (Cure MAPT FTD)
Online Support for the Management of Behavioral Symptoms: Co-Designing a Psychoeducational Intervention With Caregivers - The FTDtoolkit (#2023)
Speaker: Ana Paula Trucco (University of East Anglia)
Structural Disconnection of Frontal Cortex Underlies Deficits in Goal-Directed Behavior in Behavioral Variant Frontotemporal Degeneration (#2024)
Speaker: Melanie Matyi (University of Pennsylvania)
Elevated PM2.5 Exposure Is Associated With Earlier Age of Onset and Longer Diagnostic Delay in FTD (#2025)
Speaker: Rory Boyle (University of Pennsylvania)
Data-Driven Mapping of Known and Novel Fluid Biomarker Progression Profiles in Genetic Frontotemporal Lobar Degeneration (#2026)
Speaker: Julie De Houwer (Erasmus MC University Medical Center)
Refining Behavioural Variant Frontotemporal Dementia Classification With the Sustain Subtyping Model (#2027)
Speaker: Tran Minh Hiep Do (The University of Sydney)
White Matter Profiling in Semantic Variants of Frontotemporal Dementia and Primary Progressive Aphasia: Associations With Cortical Atrophy and Clinical Features (#2028)
Speaker: Chiara Gallingani (University of Modena and Reggio Emilia)
Macroscale Functional Connectivity Gradients in Dementia (#2029)
Speaker: Serap Özlü (German Center for Neurodegenerative Diseases (DZNE), Rostock-Greifswald, Germany)
Caregiving Burden and Support Gaps in Frontotemporal Degeneration (#2030)
Speaker: Esther Kane (The Association for Frontotemporal Degeneration)
Latent Trajectory Modelling of CDR® Plus NACC FTLD Scores in Genetic Frontotemporal Dementia (#2031)
Speaker: Giulia Campana (University of Brescia)
Visit-To-Visit Variability in Resting Heart Rate Reflects Hypermetabolic State in Symptomatic and Pre-Symptomatic Familial FTD (#2032)
Speaker: Emma Rhodes (University of Pennsylvania)
RESPALDO: A Psychoeducation Program for Hispanic Care Partners of Individuals with Language-Prominent Dementia (#2033)
Speaker: Lucia Fernandez-Romero (The University of Texas at Austin)
Semantic Dementia Disrupts Large-Scale Brain Networks of the Temporal Pole (#2034)
Speaker: Quentin Finn (Nantz National Alzheimer Center, Houston Methodist, Weill Cornell Medicine)
Resting-State fMRI Reveals Shared and Divergent Network Abnormalities in PPA-AD and PPA-FTLD (#2035)
Speaker: Karthik Sreenivasan (University of Chicago)
Reactive and Proactive Aggression are Associated with Increased Caregiver Burden in Behavioral Variant Frontotemporal Dementia (#2036)
Speaker: Levi Pettit (Vanderbilt University Medical Center)
Comparative Proteomics of CSF, Brain, and Spinal Cord Tissue in TDP-43 Compared with Non-TDP-43 Diseases (#2037)
Speaker: Jonatan Hoffmann (Technical University of Munich (TUM), School of Medicine and Health, TUM University Hospital)
Minimal Detectable Change and Minimal Clinically Important Difference for Goodness of Pronunciation in Progressive Apraxia of Speech (#2038)
Speaker: Rene Utianski (Mayo Clinic)
Characterizing Primary Progressive Aphasia in a Bilingual Hispanic Cohort in South Texas: A Retrospective Study (#2039)
Speaker: Natalia Monroy (The University of Texas at San Antonio Health Science Center)
Analysis of the Remote Visit Experience in a Sub-Cohort of ALLFTD (#2040)
Speaker: Abigail Osborne (Mayo Clinic)
Temporal Order of Clinical, Imaging and Biomarker Changes in Frontotemporal Lobar Degeneration-Associated Syndromes (#2041)
Speaker: Valeria Bracca (University of Brescia)
Objective Sleep Monitoring in Neurodegenerative Disorders Using Wearable Technology (#2042)
Speaker: Eeva Nevanranta (University of Oulu)
Biological Sex Influences Clinical Phenotype Within a Global Cohort of AD and FTD Spectrum Disorders (#2043)
Speaker: Zachary Miller (The Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco)
CSF tau368 Improves CSF p-tau Diagnostic Accuracy to Detect FTLD-tau (#2044)
Speaker: Katheryn Cousins (University of Pennsylvania)
Distinct and Shared Multimodal Neuroimaging Patterns in Clinical Frontotemporal Dementia Syndromes (#2045)
Speaker: Irene Sintini (Mayo Clinic)
Ultra–high field (7T) Intensity Gradients Reveal Cortical Microstructural Disruption Across The FTD Spectrum (#2046)
Speaker: Hamsanandini Radhakrishnan (University of Pennsylvania)
Odour Identification in Pre-Symptomatic Frontotemporal Dementia: A Longitudinal Study (#2047)
Speaker: Brigid Ryan (University of Auckland)
CureGRN: Connecting Families Affected by GRN-Associated Frontotemporal Degeneration to Awareness, Education, and Research (#2048)
Speaker: Wanda Smith (CureGRN Organization)
In Their Words: Children and Young Adults Navigating Familial Neurodegenerative Disease (#2049)
Speaker: Rowan Heffelfinger (University of California San Francisco)
Mapping Motivational Disturbances to Limbic Striatal Subdivisions Across the Frontotemporal Dementia Spectrum: A Connectivity-Based Shape Analysis (#2050)
Speaker: Angelo Arimboyutan Bumanglag (The University of Sydney)
Increased Susceptibility in Symptomatic FTLD Compared to Controls and Presymptomatic Mutation Carriers Using 7T QSM (#2051)
Speaker: Fieke A. M. Prinse (Erasmus MC)
Iron-Rich Gliosis Detected by Ultra-High Resolution 7T T2*W Ex Vivo MRI Differ Between Pathological Subtypes of Behavioral Variant Frontotemporal Dementia (#2052)
Speaker: Sheina Emrani (University of Pennsylvania)
Cerebrospinal Fluid and Blood Neurofilament Light Chain in Behavioral Variant Frontotemporal Dementia: A Systematic Review and Meta‑Analysis (#2053)
Speaker: Jamir Pitton Rissardo (Cooper University Hospital)
Digital Phenotyping of Apathy and Anhedonia In bvFTD and AD in Ecological Settings (#2054)
Speaker: Julie Behenska (Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, FrontLAB, Inserm, CNRS, AP-HP, Pitié Salpêtrière Hospital / Brain and Mind Centre, The University of Sydney / School of Psycholo)
Urinary Proteomic Profiling for Biomarker Development and Differential Diagnosis in Genetic Frontotemporal Dementia (#2055)
Speaker: Hannah Rosenheim (University College London)
Investigating the Use of the Ignite+ Digital Cognitive Assessment App in the Differential Diagnosis of Frontotemporal Dementia (#2056)
Speaker: Clementine Cheyne (UCL)
Recognising and Managing Behavioral Symptoms In FTD and FTD-ALS: Developing Training Resources for Healthcare Professionals (#2057)
Speaker: Ana Paula Trucco (University of East Anglia)
The Emotional Burden of Caring for a Person Living With Frontotemporal Dementia: A Qualitative Study (#2058)
Speaker: Ana Paula Trucco (University of East Anglia)
Cortical Atrophy and Hypometabolism Show Distinct Topographies Across Variants of Primary Progressive Aphasia (#2059)
Speaker: Yuta Katsumi (Massachusetts General Hospital and Harvard Medical School)
White Matter Integrity Predicts Downstream Trajectories of Cortical Change in Frontotemporal Dementias (#2060)
Speaker: Jessica Hazelton (The University of Sydney)
Detecting Cognitive Impairment in FTD Spectrum Syndromes Using NLP-AI Analysis of Mobile Voice-Based Neuropsychological Testing (#2061)
Speaker: Bonnie Wong (MGH)
The Pets of FTD Calendar: A Community-Driven Approach to Frontotemporal Degeneration Awareness & Connection (#2062)
Speaker: Sandra Gonzalez-Morett (Seton Hall University)
Prefrontal iTBS-rTMS Neuromodulation in bvFTD: A 12-Month Case Report (#2063)
Speaker: Kyrana Tsapkini (Johns Hopkins School of Medicine Faculty)
Ultra Low Field MR Images Correlate With 3T in Genetic FTD Cohort (#2064)
Speaker: Erin Drazich-Taylor (University College London)
Generalizable Speech Biomarkers for Behavioral Variant Frontotemporal Dementia and Alzheimer’s Disease Across Socioculturally Diverse Latino Populations (#2065)
Speaker: Franco Ferrante (Cognitive Neuroscience Center, San Andres University)
Supporting Unpaid Carers in Frontotemporal Lobar Degeneration: A Scoping Review of Behavioural Symptom Interventions (#2066)
Speaker: Ana Paula Trucco (University of East Anglia)
Proteomic Analysis of Plasma-Derived Extracellular Vesicles to Identify TDP-43-Proteinopathy Associated Biomarkers (#2067)
Speaker: Milena Lausmann (Technical University of Munich (TUM), School of Medicine and Health, TUM University Hospital)
Microglial Activation in TDP 43–Related Genetic FTD: An [¹⁸F]DPA 714 PET Study in GRN and C9orf72 Carriers (#2068)
Speaker: Tine Swartenbroekx (Erasmus Medical Center Rotterdam)
Supporting FTD Care Partners: Conceptualization of an Individualized Support Program (#2069)
Speaker: Seema Gulyani (Johns Hopkins University)
Synaptic Density Imaging in Behavioral Variant Frontotemporal Dementia: Comparing ¹⁸F-SynVesT-1 and ¹⁸F-FDG PET (#2070)
Speaker: Arman Fesharaki-Zadeh (Yale School of Medicine)
Cardiovascular Risk, White Matter Hyperintensities, and Neurofilament Light in BvFTD Across Multinational Cohorts (#2071)
Speaker: Gabriel Della Bella (Universidad de San Andres)
GABA Deficits, Synaptic Loss and Behavioural Change in FTD and PSP (#2072)
Speaker: Emily Todd (University of Cambridge)
Exploratory Plasma Neuroinflammatory Profiling in Nonfluent/Agrammatic Primary Progressive Aphasia and Primary Progressive Apraxia of Speech (#2073)
Speaker: Hiroyuki Watanabe (Mayo Clinic, Rochester, MN, USA)
Plasma Biomarkers for Early Detection of Nonfluent/Agrammatic Primary Progressive Aphasia (#2074)
Speaker: Hiroyuki Watanabe (Mayo Clinic, Rochester, MN, USA)
Transdiagnostic Biomarkers of Neurodegeneration and Cognitive Functioning in Precision Psychiatry (#2075)
Speaker: Eleanor Greenspan-Ardman (McGill)
Analysis of the Behavioral Inhibition Scale in Frontotemporal Lobar Degeneration: Findings from the ALLFTD Consortium (#2076)
Speaker: Kevin Nelson (Mayo Clinic)
Language Context Modulates Neurodegenerative Anatomy and Clinical Phenotype in Primary Progressive Aphasia (#2077)
Speaker: Fangda Leng (University of California, San Francisco)
Language Network Organization Is Associated With Brain–Behavior Relationships in Primary Progressive Aphasia Across Languages (#2078)
Speaker: Fangda Leng (University of California, San Francisco)
TRACK-FTD: Three-Dimensional Face-Tracking as an Objective Digital Marker of Empathy in FTD (#2079)
Speaker: Cem Dogdu (1 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany 2, University Hospital Bonn, University of Bonn, Bonn, Germany)
Distinct Functional Connectivity Network Trajectories Across Genetic Subtypes of Genetic Frontotemporal Dementia - Results From GENFI (#2080)
Speaker: Maurice Pasternak (Sunnybrook Research Institute)
Ex Vivo Radiomic Feature Analysis for FTLD Pathology Detection and Prediction (#2081)
Speaker: Mohammed Saqib (University of Pennsylvania)
Lessons Learned from FTD Caregiver Support Group Members: Continuing to Make Meaning Out of the Caregiver Experience (#2082)
Speaker: Katherine Brandt (Massachusetts General Hospital)
Survival Rate and Its Predictors in Genetic Frontotemporal Dementia: An International Retrospective Cohort Study (#2083)
Speaker: Arabella Bouzigues (Douglas Research Centre, McGill University)
Neurotransmitter Changes Underlying Inhibitory Control Deficits in Syndromes Associated with Frontotemporal Lobar Degeneration (#2084)
Speaker: Michelle Naessens (University of Cambridge)
Comparing Rapid and Classical Anatomical MRI Scans to Distinguish Presymptomatic and Symptomatic Frontotemporal Dementia From Controls (#2085)
Speaker: Eve Ferry-Bolder (UCL Queen Square Institute of Neurology)
PREDICTFTD – Accelerating the Validation of Predictive Liquid Biomarkers for Frontotemporal Dementia Diagnosis and Subclassification (#2086)
Speaker: Harro Seelaar (Erasmus MC University Medical Center, Rotterdam, The Netherlands)
Diffusivity Along the Perivascular Space (DTI - ALPS) Impairment in Grn-Mutated Frontotemporal Dementia: A Distinct Pathophysiological Signature (#2087)
Speaker: Edoardo Gioele Spinelli (Vita-Salute San Raffaele University)
From Patients to Partners: Empowering Frontotemporal Degeneration Research Advocacy through the Clinical Research Learning Institute (#2088)
Speaker: Lauren Massimo (University of Pennsylvania)
MRI-Based Enrichment for Progressive Supranuclear Palsy Trials in Non-Fluent Variant Primary Progressive Aphasia (#2089)
Speaker: Jesús García-Castro (Hospital de la Santa Creu i Sant Pau)
PPA SEED: Primary Progressive Aphasia Support and Education for Early Dementia (#2090)
Speaker: Darby Morhardt (Northwestern University)
Story Retelling Discourse Markers Distinguish Semantic Variant Primary Progressive Aphasia in Spanish-Speaking Latinos (#2091)
Speaker: Florentina Morello-Garcia (Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA)
Personal Values in Frontotemporal Dementia: Preliminary Insights From an Interdisciplinary Study (#2092)
Speaker: Juliana Friend (University of California, San Francisco)
Bayesian Variable Selection Approaches for Predicting Dementia Onset and Progression from ALLFTD Longitudinal Neuroimaging Data (#2093)
Speaker: Athanasia Kalogirou (Athens University of Economics and Business)
Caring for Persons Living with Primary Progressive Aphasia: An Investigation of the Male Experience (#2094)
Speaker: Lauren Dowden (Northwestern University)
Clinical and MRI Trajectories of Prediagnostic Progressive Supranuclear Palsy (#2095)
Speaker: Jesús García-Castro (Hospital de la Santa Creu i Sant Pau)
Region-Specific Anti-Inflammatory and Metabolic Effects of IL-2 Plus Abatacept in Frontotemporal Lobar Degeneration (#2096)
Speaker: Belen Pascual (Nantz National Alzheimer Center, Houston Methodist Neurological and Research Institutes, Weill Cornell Medicine)
The Emotional Impact of Frontotemporal Dementia on Family Caregivers: A Lived-Experience Survey (#2097)
Speaker: Maria Beers (Boston University)
Time to Diagnosis in FTLD Clinical Syndromes in Latin America: An Analysis of The RedLat Consortium (#2098)
Speaker: Nahuel Magrath Guimet (Fleni)
Staging Primary Tauopathies With Tau Proteoforms (#2099)
Speaker: Takumi Nakamura (Washington University in Saint Louis)
Track-Weighted Functional Connectivity Reveals Divergent Patterns of Decreased and Increased Connectivity in Primary Progressive Aphasia (#2100)
Speaker: Sophie Matis (The University of Sydney)
Synaptic Density Imaging in Behavioral Variant Frontotemporal Dementia: Comparing ¹⁸F-SynVesT-1 and ¹⁸F-FDG PET (#2101)
Speaker: Arman Fesharaki-Zadeh (Yale School of Medicine)
Earlier Referral, Better Conversations: Practice-Changing Findings from a Multicentre Randomised Controlled Teletherapy Trial in Primary Progressive Aphasia and Rare Dementias (#2102)
Speaker: Anna Volkmer (UCL)
Development of Frontotemporal Lobar Degeneration Syndrome-Specific Imaging Templates for Prediction of Phenotype Conversion (#2103)
Speaker: Ashley Heywood (University of California, San Francisco)
Genome Wide Association Study Implicates Neuregulin in the Risk of Semantic Dementia (#2104)
Speaker: Malik Nassan (Mesulam Institute for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL)
CSF MMP10 is Increased in MAPT-Related FTD and Correlates with Disease Severity (#2105)
Speaker: Hannah Rosenheim (University College London)
Quantitative Susceptibility Mapping in the GENFI Cohort (#2106)
Speaker: Eva Cullen (University College London)
Early Identification of Neurodegenerative Dementias In a Psychiatry Clinic: A Progress Report (#2107)
Speaker: Şevval Tiryaki (Hacettepe University Medical School)
1:30 PM - 3:30 PM
Salon H
Plenary Session 3 - Update on Genetics and Neuropath of FTD
1:30 PM - 2:00 PM
Structural Classification of FTLD
Speaker: Benjamin Ryskeldi-Falcon (UK)
2:00 PM - 2:30 PM
Genes and Risk Factors for FTLD Subtypes
Speaker: Rosa Rademakers (Belgium)
2:30 PM - 2:45 PM
Unraveling a Hidden Legacy: GRN, TMEM106B, and My Family’s FTD Journey (#2108)
Speaker: Jacquelyn Shapiro (CureGRN Champion, Association for Frontotemporal Degeneration Ambassador)
2:45 PM - 3:00 PM
Structural Polymorphism Drives Tau Seeding Potency and Disease Aggressiveness in Progressive Supranuclear Palsy (#2109)
Speaker: Hong Xu (University of Pennsylvania)
3:00 PM - 3:15 PM
The Shared Genetic Architecture of TDP-43 Spectrum: Bridging Clinical FTLD and Neuropathological Endophenotypes (#2110)
Speaker: Maulikkumar Patel (Washington University School of Medicine at Saint Louis)
3:15 PM - 3:30 PM
Cross-Seeding of tau by TMEM106B Fibrils in a Human Neurodegenerative Disease Model (#2111)
Speaker: Anthony Fitzpatrick (Columbia University)
3:30 PM - 4:00 PM
Franklin Hall B
Coffee Break / Visit Exhibits
4:00 PM - 4:15 PM
Salon H
Introduction to The Holly Hayes Lecture on FTD
Speaker: Marsel Mesulam (USA)
4:15 PM - 4:45 PM
Salon H
Holly Hayes Annual Lecture on FTD
Speaker: Susan Dickinson (USA)
More Info
4:45 PM - 5:30 PM
Salon H
Panel: Recent Advances in Biomarkers and Emerging Therapies Shaping the Research Landscape
Moderator: Nicole Bjorklund (USA)
Panelists: Adam Boxer (USA), Alexander Murley (UK) & Yolande Pijnenburg (The Netherlands)
5:30 PM - 6:00 PM
Salon H
ISFTD Business Meeting
Saturday, October 10, 2026
8:30 AM - 10:00 AM
Salon H
Plenary Session 4 - Clinical Trials/Trial Design
8:30 AM - 9:00 AM
Digital Health Assessments in FTLD
Speaker: Adam Staffaroni (USA)
9:00 AM - 9:30 AM
Update on Tau Targeting Trials in PSP/CBS
Speaker: Günter Höglinger (Germany)
9:30 AM - 10:00 AM
From Care to Clinical Trials: Centering Individuals and Families in FTD Research
Speaker: Lauren Massimo (University of Pennsylvania)
10:00 AM - 10:30 AM
Franklin Hall B
Coffee Break / Visit Exhibits
10:30 AM - 12:00 PM
Salon I-L
Abstracts Session 3.1 - Genetics
10:30 AM - 10:45 AM
A Large-Scale GWAS of Clinical Frontotemporal Dementia Identifies Known and Emerging Associated Loci (#3001)
Speaker: Lianne Reus (Amsterdam UMC | University College London)
10:45 AM - 11:00 AM
Genetic Predisposition for Developmental Dyslexia in Semantic Variant Primary Progressive Aphasia (#3002)
Speaker: Sterre de Boer (Alzheimercentrum Amsterdam)
11:00 AM - 11:15 AM
Chinese National Multicenter Genomic Study on Frontotemporal Dementia: CHIFGENS (#3003)
Speaker: Liyong Wu (Xuanwu Hospital, Capital Medical University, Beijing, China)
11:15 AM - 11:30 AM
Genome Wide Association Studies Characterize Risk Loci Underlying CBD and PiD Biology (#3004)
Speaker: Nicole Tamvaka (Mayo Clinic)
11:30 AM - 11:45 AM
A Single Nucleus Meta-Atlas of FTLD-TDP and ALS Reveals Cell Type Specific Cryptic Splicing and Alternative Polyadenylation (#3005)
Speaker: Alice Maria Giani (Icahn School of Medicine at Mount Sinai)
11:45 AM - 11:48 AM
Frontotemporal Lobar Degeneration associated with TBK1 Variants: Clinical and Neuropathological Features (#3006)
Speaker: Manizhe Eslami-Amirabadi (University of Washington)
11:48 AM - 11:51 AM
Repeat Instability of the c9orf72 Expansion in Blood Differs Between Patients With Frontotemporal Dementia or Amyotrophic Lateral Sclerosis (#3007)
Speaker: Mathieu Barbier (Paris Brain Institute)
11:51 AM - 11:54 AM
SQSTM1 Mutations in Chinese Sporadic Frontotemporal Dementia: Genetic Frequency, Clinical Heterogeneity, and Functional Insights (#3008)
Speaker: Haitian Nan (Xuanwu Hospital)
11:54 AM - 11:57 AM
Predictive Genetic Counseling Enhances Empowerment in Individuals At-Risk for Frontotemporal Dementia (#3009)
Speaker: Laynie Dratch (University of Pennsylania)
11:57 AM - 12:00 PM
Exploring Causative Role of Missense GRN Variants in bvFTD (#3010)
Speaker: Anna CHAUVEAU (Lausanne University Hospital (CHUV) and University of Lausanne)
10:30 AM - 12:00 PM
Salon H
Abstracts Session 3.2 - Behaviour / Psychiatry
10:30 AM - 10:45 AM
International Consensus Research Criteria for the bvFTD Phenocopy Syndrome (#3011)
Speaker: Welmoed Krudop (Amsterdam UMC)
10:45 AM - 11:00 AM
The Diagnostic Evidence for Behavioural Variant Frontotemporal Dementia in Criminal Court Reports (#3012)
Speaker: Joshua Flavell (The University of Queensland)
11:00 AM - 11:15 AM
Characterizing Pathological Laughing and Crying in Frontotemporal Dementia (#3013)
Speaker: Kaancan Deniz (University of California San Francisco)
11:15 AM - 11:30 AM
Early-Stage bvFTD Cases Show a Distinct Sleep Disturbance Profile Compared to Other Neurodegenerative Diseases (#3014)
Speaker: Mika Kinnunen (University of Eastern Finland)
11:30 AM - 11:45 AM
A 6-Second Speech Task Detects Early Changes in FTD Mutation Carriers (#3015)
Speaker: Amelia Blesius (University College London)
11:45 AM - 11:48 AM
Neural Synchrony During Naturalistic fMRI Tracks Social Behavior Phenotype Beyond Atrophy in Behavioral Variant Frontotemporal Dementia (#3016)
Speaker: Jayden Lee (Vanderbilt University Medical Center)
11:48 AM - 11:51 AM
Contributions of Deficits in Goal-Directed Behavior to Functional Impairment in Behavioral Variant Frontotemporal Degeneration (#3017)
Speaker: Melanie Matyi (University of Pennsylvania)
11:51 AM - 11:54 AM
Theory of Mind of Emotions Test (TOMET): A Novel Image-Based Test of Affective Theory of Mind for Behavioural Variant Frontotemporal Dementia (#3018)
Speaker: Joshua Flavell (The University of Queensland)
11:54 AM - 11:57 AM
Bipolar Disorder preceding bvFTD and PSP-F: A Case Series (#3019)
Speaker: Şevval Tiryaki (Hacettepe University Medical School)
11:57 AM - 12:00 PM
Effect of Long-Term Left Dorsolateral Prefrontal Cortex Brain Stimulation on Neuropsychiatric Profiles in Primary Progressive Aphasia (#3020)
Speaker: Maria Valles-Salgado (Hospital Clinico San Carlos)
12:00 PM - 1:30 PM
Franklin Hall B
Poster Session 3 / Lunch
Ropinirole, an Orally Available Clinical Candidate for Sporadic FTLD: Subtype-Independent Neuronal Rescue via Lysosome/Autophagy Modulation in Patient-Derived IPSC Models. (#3021)
Speaker: Hiroshi Kokubu (K Pharma, Inc.)
Reading the Gene in the Eye: Clinical Discrimination and Metacognition in Genetic FTD (#3022)
Speaker: Alexandre Morin (CHU ROUEN)
Ultra-High Field MRI Shows Signs of Neurodegeneration but Not Neuroinflammation in Frontotemporal Lobar Degeneration (#3023)
Speaker: Fieke A. M. Prinse (Erasmus MC)
Genetic Spectrum of Frontotemporal Dementia in Japan: Results from the FTLD-J Registry (#3024)
Speaker: Kohji Mori (The University of Osaka)
Communication Participation Goal Response in Primary Progressive Aphasia with Co-occurring Apraxia of Speech (#3025)
Speaker: Rene Utianski (Mayo Clinic)
Vortioxetine for Affective Symptoms in Behavioral Variant Frontotemporal Dementia: Preliminary Results of an Open-Label Pilot Study (#3026)
Speaker: Christopher Morrow (Johns Hopkins School of Medicine)
Lexical Properties Predict Anomia Treatment Outcomes for Bilinguals with Logopenic and Semantic Variants of Primary Progressive Aphasia (#3027)
Speaker: Wenfu Bao (The University of Texas at Austin)
Cognitive and Neuroimaging Predictors of Response to Transcranial Magnetic Stimulation and Language Therapy in Primary Progressive Aphasia (#3028)
Speaker: Lucia Fernandez-Romero (The University of Texas at Austin)
Identification of RNA Binding Proteins Interacting with Upstream of C9orf72 GGGGCC Repeat (#3029)
Speaker: Shiho Gotoh (The University of Osaka Graduate School of Medicine)
Sex Mediates the Relationship Between Agitation and Grey Matter Volume in Progressive Supranuclear Palsy (#3030)
Speaker: Celine N. Sakran (University Health Network)
Design of Phase 2A Clinical Trial of Neflamapimod in Patients With Non-Fluent Variant Primary Progressive Aphasia (#3031)
Speaker: David J. Irwin (Penn Frontotemporal Degeneration Center, Perelman School of Medicine, University of Pennsylvania)
Data Sharing Behaviors and Outcomes Among AD/ADRD Investigators by Genetic Data Use (#3032)
Speaker: Catherine Scipion (Georgia State University School of Public Health)
Operational Lessons from the Neurofilament Surveillance Project (NSP) (#3033)
Speaker: Rachel Acuna-Narvaez (The Bluefield Project to Cure FTD)
Combined Transcranial Magnetic Stimulation and Transcranial Electrical Stimulation Associated With Language Therapy in Primary Progressive Aphasia: Protocol of a Double-Blind, Parallel, and Randomized Clinical Trial (#3034)
Speaker: Lucia Fernandez-Romero (The University of Texas at Austin)
SORL1-Associated Early Onset Dysexecutive/Behavioral Variant of Alzheimer’s Disease: An Expansion of This Rare Phenotype (#3035)
Speaker: Ashleigh Hansen (Cedars-Sinai)
Corticobasal Functional Scale (CBFS) Captures Disease Features and Severity in Frontotemporal Lobar Degeneration (FTLD) Syndromes (#3036)
Speaker: Hilary Heuer (UCSF)
Blunted Satiety Responses and fMRI Changes Associated With Dysregulated Eating in bvFTD (#3037)
Speaker: Laura I Van Hove (KU Leuven)
Overview of a Large Single-Site Familial FTD Cohort (#3038)
Speaker: Erin Krahn (Massachusetts General Hospital)
GABAergic Modulation of Beta Power During Response Inhibition in PSP and bvFTD (#3039)
Speaker: Laura Hughes (University of Cambridge)
Imaging Transcriptomics in Presymptomatic Stage of Genetic Frontotemporal Dementia (#3040)
Speaker: Valeria Bracca (University of Brescia)
Speech-Language Interventions in Primary Progressive Aphasia: A Continuum of Restitutive, Compensatory, Partner-Focused, and Psychosocial Approaches (#3041)
Speaker: Maya Henry (University of Texas at Austin)
Long-Read Sequencing Advances Diagnostics and Discovery in Frontotemporal Dementia (#3042)
Speaker: Livija Bardina (Erasmus Medical Center)
Reach and Pragmatic-Readiness Considerations in an Ongoing Telehealth Trial for Primary Progressive Aphasia (#3043)
Speaker: Emily Rogalski (University of Chicago)
Shared Risk, Shared Strength: Peer Support in Genetic FTD (#3044)
Speaker: Kim Jenny (The Association for Frontotemporal Degeneration)
Unraveling the Molecular Complexity of FTLD-TDP Subtypes Through Spatial Transcriptomics (#3045)
Speaker: Maja Højvang Sørensen (University of Pennsylvania)
Investigating the Relationship Between VCP Substrate Structure and VCP-Dependent Degradation (#3046)
Speaker: Katherine Xia (University of Pennsylvania)
A Collaborative Framework for Proactive Monitoring and Support in Genetically At-Risk ALS and FTD Populations (#3047)
Speaker: Cassandra Haddad (ALS Hope/End the Legacy)
Educational Attainment and Sex Modulate Clinical Outcomes in Genetic Frontotemporal Dementia (#3048)
Speaker: Valeria Bracca (University of Brescia)
Phenotypic Homogeneity in a Family With MAPT N296D-Related Frontotemporal Dementia (#3049)
Speaker: Annika Brouwer (Erasmus MC)
Symptomatic Trials for Frontotemporal Dementia – Lessons From the Nabilone-FTD Trial (#3050)
Speaker: Simon Ducharme (Douglas Institute)
Randomized Controlled Study of Near-Infrared Light Modulation for Behavioral Variant Frontotemporal Dementia (#3051)
Speaker: Min Chu (Xuanwu Hospital, Capital Medical University)
Clinical Benefits and Neural Mechanism of Action of Non-invasive Brain Stimulation in Primary Progressive Aphasia (#3052)
Speaker: Alexandra Touroutoglou (Massachusetts General Hospital/Harvard Medical School)
Music-based Empathy Therapy for Frontotemporal Dementia: A Feasibility Pilot (#3053)
Speaker: Kaitlin Seibert (Cleveland Clinic)
Testing Targeted Progranulin Gene Therapy for FTD Due to GRN Mutations (#3054)
Speaker: Azariah Kaplelach (University of Alabama at Birmingham)
Posterior Cortical Atrophy in Frontotemporal Lobar Degeneration Caused by Progranulin Gene Mutation: A Case Report (#3055)
Speaker: Paula Canasto (Hospital Clínic de Barcelona)
Therapeutic Evaluation of AAV-Mediated Delivery of Granulins in a Mouse Model of FTD Caused By Loss of Progranulin (#3056)
Speaker: Tom Kukar (Emory University)
Single-Nucleus RNA Sequencing Reveals Glial Alterations in FTLD-TDP Type A With and Without GRN Mutations (#3057)
Speaker: Elise Coopman (VIB-UAntwerp Center for Molecular Neurology)
Distinct Neuronal Vulnerability States Across FTLD‑TDP Subtypes Revealed by Single-Nucleus Transcriptomics (#3058)
Speaker: Júlia Faura (VIB-UAntwerp Center for Molecular Neurology)
GABAergic Regulation of Action-Outcome Priors in Conditions Associated With Frontotemporal Lobar Degeneration (#3059)
Speaker: Rebecca Williams (University of Cambridge)
A TDP-43 Functional Reporter for the Adjudication of Potentially Pathogenic Variants (#3060)
Speaker: Alexander Ehrenberg (University of California, San Francisco)
Distribution-Aware Lysosomal Phenotyping to Prioritize FTD/ALS-Linked Perturbations in Human iPSC-Derived Neurons (#3061)
Speaker: Claire Peterson (University of Alabama at Birmingham)
Literature Review of Education Interventions for Healthcare Students to Develop Empathy for Patients with Dementia (#3062)
Speaker: Aimen Vanood (Mayo Clinic)
Serum Neuron-Derived Extracellular Vesicles in Genetic Frontotemporal Dementia (#3063)
Speaker: Chiara Fenoglio (IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, University of Milan)
Cross-Cultural Comparison of Early Behavioral and Social Cognitive Changes in the Behavioral Variant of Frontotemporal Dementia (#3064)
Speaker: Fan Ji (KU Leuven)
No Evidence of a Broad Autism Phenotype or Schizotypy in Presymptomatic Mutation Carriers From the GENEFI Cohort (#3065)
Speaker: Phoebe Foster (University College London (UCL))
Residue-Specific FUS Arginine Hypomethylation Converges on RGG2 and Regulates Phase Separation in FTLD-FUS (#3066)
Speaker: Ryuta Morihara (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
In Vitro Experimental Validation Pipeline for Discovering Small‑Molecule Inhibitors of TDP‑43 Aggregation (#3067)
Speaker: Lea El Hajjar (Institut du cerveau)
Investigating Apathy Across Disease Stages and Genetic Groups in Frontotemporal Dementia (FTD) Within the GENetic FTD Initiative (GENFI) Cohort (#3068)
Speaker: Sophie Farley (University College London)
Integrating Transcriptomics, Stepwise Functional Connectivity and Atrophy to Map Molecular Vulnerability Across the FTLD Spectrum (#3069)
Speaker: Francesca Orlandi (Ospedale San Raffaele)
Phenotypic Heterogeneity and Polygenic Risk Burden in a Large GRN-Associated FTLD Kindred (#3070)
Speaker: Pawan Kumar (Washington University School of Medicine in St. Louis)
Long-Read Sequencing Reveals Cell Type-Resolved Vulnerabilities to TDP-43 Pathology and Its Downstream Consequences (#3071)
Speaker: Liam Horan-Portelance (University of California, San Francisco)
MAPT FTD: The Missing Population in Tau Drug Development (#3072)
Speaker: Swetha Mohan (Cure MAPT FTD)
Stem Cell Models Highlight Proteostasis Defects as Key Features in Genetic FTLD (#3073)
Speaker: Anna CHAUVEAU (Lausanne University Hospital (CHUV) and University of Lausanne)
Understanding Anhedonia and Apathy Symptom Networks in Behavioural Variant Frontotemporal Dementia (#3074)
Speaker: Lulu Zhang (The University of Sydney)
Effect of Semantic and Metacognitive Rehabilitation in Semantic Variant Primary Progressive Aphasia: A Single-Case Experimental Study (#3075)
Speaker: Sarah Maso (Toulouse NeuroImaging Center (Tonic-Inserm))
Personalized Intermittent Theta-Burst Stimulation in Frontotemporal Dementia: A Randomized Sham-Controlled Trial (#3076)
Speaker: Alessia Cerino (University of Brescia)
The Value of Multivariate Clinical Patterns Using Representational Similarity Analysis in Differentiating Frontotemporal Dementia From Primary Psychiatric Disorders (#3077)
Speaker: Sterre de Boer (Alzheimercentrum Amsterdam)
Rare Genetic Variants Influence Serum Neurofilament Light Chain Levels in Genetic Frontotemporal Dementia: A Genfi Study (#3078)
Speaker: Saira Mirza (Sunnybrook Health Sciences Center)
Study Design of PRO-201, A Phase 2a Study of the Novel, CNS-penetrant MAP4K Inhibitor Prosetin in Participants With bvFTD (#3079)
Speaker: Erin Fleming (ProJenX)
Nasu–Hakola Disease as a Rare Mimic of Frontotemporal Dementia: An Italian Case Series and Systematic Review (#3080)
Speaker: Paola Caroppo (Neurology 8 – Dementia and degenerative diseases of CNS Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano)
Feasibility of Wearable Sensor-Based Monitoring of Real-World Communication and Activity in Primary Progressive Aphasia (#3081)
Speaker: Angela Roberts (Western University)
BvFTD Caused by an OPTN c.493C>T Mutation: An Extensive Case Report (#3082)
Speaker: Roberta Gianelli (Vrije Universiteit)
Pathogenic Grn Mutation in a Biomarker-Confirmed Early-Onset Alzheimer’s Disease Patient Eligible to Anti-Amyloid Therapy (#3083)
Speaker: Edoardo Gioele Spinelli (Vita-Salute San Raffaele University)
Disastrous Consequences of Incorrect FTD Diagnosis: A Case Series (#3084)
Speaker: Y.A.L. Pijnenburg (Amsterdam University Medical center)
GRN-Associated FTD in the Era of Early Genetic Identification: Mechanisms, Emerging Therapies, and Implications for Genetic Counseling (#3085)
Speaker: Wanda Smith (CureGRN Organization)
Annexin A11 Co-Localizes with Synaptic and Cytoskeletal Protein in Healthy Neurons and Co-Aggregates with Synaptic and Cytoskeletal Proteins in FTLD-TDP Post-Mortem Brains (#3086)
Speaker: Katherine Dorfman (University of Pennsylvania)
Phenotypic Heterogeneity and Diagnostic Trajectories in Patients With CSF1R Gene Variants: A Case Series (#3087)
Speaker: Ramiro Ruiz (National Institute of Neurology and Neurosurgery of Mexico)
Mass Spectrometry Reveals a Distinct Molecular Signature in FTD Self-Organizing, Single Rosette-Cortical Organoids (#3088)
Speaker: Merci Best (Boston University)
Long-term Overexpression of Carboxy-Terminal Blocked Progranulin Corrects Behavioral, Lysosomal, and Microglial Phenotypes up to One Year Post Injection (#3089)
Speaker: Vivianna DeNittis (University of Alabama at Birmingham)
Variants of Uncertain Significance in Frontotemporal Dementia: The Need for an Integrated Translational Approach (#3090)
Speaker: Nahuel Magrath Guimet (Fleni)
A Case of GRN-FTD Presenting with Chorea (#3091)
Speaker: Jake Levy (University of California San Francisco)
Hiryama Disease Presentation with FrontHiryama Disease Presentation With Frontal Signs in a Patient With TARDBP Mutation and a Strong Family History of FTD (#3092)
Speaker: Alicia Parker (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases)
Neuropsychiatric Symptoms Map Accelerated Whole-Brain and Circuit Specific Clocks in Frontotemporal Dementia and Alzheimer’s Disease (#3093)
Speaker: Jessica Hazelton (The University of Sydney)
Gene Expression Signatures in Genetic and Sporadic Frontotemporal Dementia: Insight Into Autophagy, Inflammation, and Oxidative Stress (#3094)
Speaker: Chiara Fenoglio (IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, University of Milan)
Conditional Wild-Type Human TDP-43 Transgenic Mouse Model Recapitulates Key Pathological and Behavioral Features of FTD (#3095)
Speaker: Emmanuel Adebanjo (Northwestern University, Feinberg School of Medicine)
Aβ42 Induces Selective Degeneration in Hippocampal Cells of Aged Monkeys (#3096)
Speaker: Jiawei Zhang (Department of neurology,The Second Clinical Medical College , Jinan University (Shenzhen People's Hospital), Shenzhen 518020,China. The First Affiliated Hospital, Jinan University, Guangzhou)
ZNF746/PARIS as a Potential Pathological Hub Extending from Parkinson’s Disease to Frontotemporal Dementia (#3097)
Speaker: Zhaohao Zeng (Shenzhen People's Hospital)
CSF Proteome Signatures in FTD Are Dependent on the Presence of AD Copathology (#3098)
Speaker: Frederika Malichova (Amsterdam UMC)
Predictors of Word-Level Treatment Response in Primary Progressive Aphasia: A Post-Hoc Analysis of a Randomized Controlled Trial of Transcranial Magnetic Stimulation (#3099)
Speaker: Jordi A Matias-Guiu (Hospital Clinico San Carlos)
Sensorimotor Dysfunction in Semantic Variant Primary Progressive Aphasia: An RDoC-Based Clinical Analysis (#3100)
Speaker: Deissy Milena Garcia García (Hospital Universitario Fundación Santa Fe, Hospital Universitario San Ignacio)
A "Double-Hit" Model of Proteostasis Collapse? Linking OPTN c.493C>T and TMEM106B Processing to Pure FTD-TDP Type A (#3101)
Speaker: Roberta Giannelli (Vrije Universiteit Amsterdam)
Clinical and Neuroanatomical Characterization of a Colombian Patient With Semantic Variant Primary Progressive Aphasia Carrying a TARDBP p.i383v Variant (#3102)
Speaker: Luisa Fernanda Goméz (Universidad Javeriana)
Building Opportunities for Collaboration Between Anthropology and the Clinical Neurosciences to Improve Frontotemporal Dementia Diagnosis and Care (#3103)
Speaker: Juliana Friend (University of California, San Francisco)
Behavioral Variant Frontotemporal Dementia With Emergent Semantic Impairment Associated With the MAPT p.s305s Variant: A Case Report (#3104)
Speaker: Deissy Milena Garcia García (Hospital Universitario Fundación Santa Fe, Hospital Universitario San Ignacio)
Semantic-Variant Primary Progressive Aphasia Associated with SOD1 p.Phe21Leu (c.63C>G): A Case Report (#3105)
Speaker: Darwin Abril (Hospital Universitario San Ignacio)
A Neurodevelopmental Basis for GRN-Associated Frontotemporal Dementia Revealed by Human Cortical Organoids (#3106)
Speaker: Martyna Grochowska (National Institutes of Health, National Institute on Aging)
Progranulin Regulates PPT1 Level and Activity in the Lysosome (#3107)
Speaker: Weiguo He (Cornell University)
ER-Microtubule Contact Misregulation Via PP1 Misregulation as a Converging Mechanism for TDP-43 and tau Mutations in Frontotemporal Dementia (#3108)
Speaker: Yvette Wong (Northwestern University Feinberg School of Medicine)
TMEM106B and Resilience in FTLD-GRN: Lessons for Counselling and Trial Design (#3109)
Speaker: Marijne Vandebergh (VIB-UAntwerp Center for Molecular Neurology)
Functional Characterization of the TMEM106B Locus (#3110)
Speaker: Cristina Vicente (VIB-UAntwerp Center for Molecular Neurology)
1:30 PM - 3:00 PM
Salon H
Abstracts Session 4.1 - Pathomechanism
1:30 PM - 1:45 PM
Recurrent patterns of TOP1-Mediated Neuronal Genomic Damage Shared by Major Neurodegenerative Disorders (#3111)
Speaker: Zinan Zhou (University of Chicago)
1:45 PM - 2:00 PM
Untargeted Cerebrospinal Fluid Proteomics in Sporadic Frontotemporal Dementia Points Toward Shared Biology With Genetic Cases (#3112)
Speaker: Luc Hartog (Alzheimercenter Amsterdam | Amsterdam UMC)
2:00 PM - 2:15 PM
Progranulin Secretion Is Not Necessary to Prevent FTD-Related Pathology in Vivo (#3113)
Speaker: Mackenzie Love (University of Alabama at Birmingham)
2:15 PM - 2:30 PM
Single-Cell Transcriptomic Atlas of Frontoinsular Cortex Reveals Molecular Correlates of Selective Neuronal Vulnerability in FTD (#3114)
Speaker: Arnar Breevoort (University of California, San Francisco)
2:30 PM - 2:45 PM
TMEM106B Regulates Synaptic Maintenance Through Lysosomal Positioning in Neurons (#3115)
Speaker: Miranda Lastra Osua (VIB-Center for Molecular Neurology)
2:45 PM - 2:48 PM
Phosphorylation Modifies Annexin A11’s Effect on TDP-43 Aggregation (#3116)
Speaker: Courtney Smith (University of Pennsylvania)
2:48 PM - 2:51 PM
Large-Scale Single-Cell Profiling Reveals Memory B Cell Expansion in Progressive Supranuclear Palsy (#3117)
Speaker: Jennifer Yokoyama (University of California, San Francisco)
2:51 PM - 2:54 PM
Secreted Signals: Tracing Human Microglial Communication in Frontotemporal Dementia in Vivo (#3118)
Speaker: Maxim van Hoek (VIB-UAntwerp Center for Molecular Neurology)
2:54 PM - 2:57 PM
Selective Vulnerability and Resilience in the FTD Thalamus (#3119)
Speaker: Elise Marsan (National Institutes of Health, National Institute on Aging)
2:57 PM - 3:00 PM
Contribution of Astrocytic SPARCL1 to Cortical Synaptic Dysfunction In C9orf72-FTD/ALS (#3120)
Speaker: Robert Culibrk (Barrow Neurological Institute)
1:30 PM - 3:00 PM
Salon I-L
Abstracts Session 4.2 - Clinical Overlap / Care Management
1:30 PM - 1:45 PM
C9orf72 Specific Hypothalamic Atrophy in ALS-FTD Spectrum Precedes Phenoconversion (#3121)
Speaker: Noah Schweitzer (University of Pennsylvania)
1:45 PM - 2:00 PM
FTD & the U.S. Criminal Legal System: What Care Partners Reveal about Gaps (#3122)
Speaker: Victoria Helmly (Georgia State University)
2:00 PM - 2:15 PM
Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders (#3123)
Speaker: Jennifer L. Whitwell, Ph.D (Mayo Clinic)
2:15 PM - 2:30 PM
Wearable Actigraphy Captures Heterogeneous Motor Symptoms in Frontotemporal Dementia (#3124)
Speaker: Emily Paolillo (UCSF Fein Memory and Aging Center)
2:15 PM - 2:30 PM
Early Detection of Frontotemporal dementia (EDoF): Developing Multimodal Digital Biomarkers for FTD and ALS (#3127)
Speaker: Rhian Convery (University College London)
2:30 PM - 2:45 PM
The Lived Experience of Being At-Risk for Genetic Frontotemporal Dementia: Impact, Challenges, Coping, and Need for Support (#3125)
Speaker: Jessica Panman (Erasmus Medical Center)
2:45 PM - 2:48 PM
The Critical Role of Data in Advancing Frontotemporal Degeneration Research: Insights from the FTD Disorders Registry (#3126)
Speaker: Carrie Milliard (FTD Disorders Registry)
2:51 PM - 2:54 PM
Successful Strategies for Recruiting FTD Care Partners: (#3128)
Speaker: Allison Lindauer (Oregon Health & Science University)
2:54 PM - 2:57 PM
Portable Digital Biomarkers of Motor Dysfunction Across the FTD-ALS Spectrum (#3129)
Speaker: Luna Nordenström (University College London (UCL))
2:57 PM - 3:00 PM
Investigation of a Familial C9orf72 Penetrance Score in FTD and ALS (#3130)
Speaker: Nadia Dehghani (Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA)
3:00 PM - 3:30 PM
Franklin Hall B
Coffee Break / Visit Exhibits
3:30 PM - 5:00 PM
Salon H
Plenary Session 5 - Pathomechanisms and Translation
3:30 PM - 4:00 PM
Disruption of RNA Metabolism and Emerging Therapeutic Targets
Speaker: Clotilde Lagier-Tourenne (USA)
4:00 PM - 4:30 PM
Transynaptic Tau Spread in Tauopathies
Speaker: Tara Spires-Jones (UK)
4:30 PM - 4:45 PM
Modeling Strain-Specific Tau Pathology in hiPSC-Derived Cerebral Organoids: Insights into FTLD and Sporadic Tauopathies (#3131)
Speaker: Xiaohuan Sun (University of Pennsylvania)
4:45 PM - 5:00 PM
PGRN Deficiency–Driven Lysosomal Failure Triggers Microglial Degeneration and Accelerates Neurodegenerative Pathology (#3132)
Speaker: Paula Polanco Miquel (VIB Center for Molecular Neurology)
5:00 PM - 7:00 PM
Salon I
ISTAART PIA Workshop: Integrating Diversity into Frontotemporal Dementia Research: From Biological Insight to Equitable Clinical Practice
Sunday, October 11, 2026
8:30 AM - 10:30 AM
Salon H
Plenary Session 6 - HOT Topics
8:30 AM - 8:45 AM
Standardizing Excellence: Training Clinical Research Coordinators for FTD Trials (#4001)
Speaker: Shana Dodge (The Association for Frontotemporal Degeneration)
8:45 AM - 9:00 AM
Biomarkers, Efficacy, and Safety of PR006, an Investigational AAV9 Gene-Therapy in Frontotemporal Dementia Patients with GRN Mutations (#4002)
Speaker: Travis Lewis (Eli Lilly and Company)
9:00 AM - 9:15 AM
Inheriting a Legacy (#4003)
Speaker: Linde Jacobs (Cure MAPT FTD)
9:15 AM - 9:30 AM
ASPIRE-FTD Study Update: A Phase 1/2 Study to Evaluate AVB-101 in FTD with GRN Mutations (#4004)
Speaker: Yi-Ge Huang (AviadoBio Ltd, London)
9:30 AM - 9:45 AM
Phase 1B/2A Data: Inhibition of Progranulin Binding to Sortilin With VES001 in Grn Mutation Carriers Is Well-Tolerated and Normalizes Plasma and CSF Progranulin (#4005)
Speaker: Mads Kjolby (Vesper Bio)
9:45 AM - 10:00 AM
First-in-Human Evaluation of [¹⁸F]ACI-19626, a Novel TDP-43 PET Tracer (#4006)
Speaker: Tamara Seredenina (AC Immune)
10:00 AM - 10:15 AM
Initial Biomarker Results from A Phase 2a Clinical Trial of Neflamapimod in Patients with Nonfluent Variant Primary Progressive Aphasia (#4007)
Speaker: David J. Irwin (Penn Frontotemporal Degeneration Center, Perelman School of Medicine, University of Pennsylvania)
10:30 AM - 11:00 AM
Salon H
Special Session & Closing Remarks